Differential Toxicity of Nuclear RNA Foci Versus Dipeptide Repeat Proteins in a Drosophila Model of C9ORF72 FTD/ALS

Dipeptide repeat (DPR) proteins are toxic in various models of FTD/ALS with GGGGCC (G(4)C(2)) repeat expansion. However, it is unclear whether nuclear G(4)C(2) RNA foci also induce neurotoxicity. Here, we describe a novel Drosophila model expressing 160 G(4)C(2) repeats (160R) flanked by human intro...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Tran, Helene, Almeida, Sandra, Moore, Jill, Gendron, Tania F., Chalasani, UmaDevi, Lu, Yubing, Du, Xing, Nickerson, Jeffrey A., Petrucelli, Leonard, Weng, Zhiping, Gao, Fen-Biao
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589299/
https://ncbi.nlm.nih.gov/pubmed/26402604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.09.015
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados