Differential Toxicity of Nuclear RNA Foci Versus Dipeptide Repeat Proteins in a Drosophila Model of C9ORF72 FTD/ALS

Dipeptide repeat (DPR) proteins are toxic in various models of FTD/ALS with GGGGCC (G(4)C(2)) repeat expansion. However, it is unclear whether nuclear G(4)C(2) RNA foci also induce neurotoxicity. Here, we describe a novel Drosophila model expressing 160 G(4)C(2) repeats (160R) flanked by human intro...

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Veröffentlicht in:Neuron
Hauptverfasser: Tran, Helene, Almeida, Sandra, Moore, Jill, Gendron, Tania F., Chalasani, UmaDevi, Lu, Yubing, Du, Xing, Nickerson, Jeffrey A., Petrucelli, Leonard, Weng, Zhiping, Gao, Fen-Biao
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589299/
https://ncbi.nlm.nih.gov/pubmed/26402604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.09.015
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