IL-1βR-dependent priming of antitumor CD4(+) T cells and sustained antitumor immunity after peri-tumoral treatment with MSU and mycobacteria

Local immune-activating therapies seek to improve the presentation of tumor antigen, thereby promoting the activation of antitumor CD8(+) T cells and delaying tumor growth. Surprisingly, little is known about the ability of these therapies to stimulate antitumor CD4(+) T cells. We examined tumor-spe...

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Detalles Bibliográficos
Publicado en:Oncoimmunology
Main Authors: Kuhn, Sabine, Yang, Jianping, Hyde, Evelyn J, Harper, Jacquie L, Kirman, Joanna R, Ronchese, Franca
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2015
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589042/
https://ncbi.nlm.nih.gov/pubmed/26451307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1042199
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