CD56(bright) NK cells exhibit potent antitumor responses following IL-15 priming

NK cells, lymphocytes of the innate immune system, are important for defense against infectious pathogens and cancer. Classically, the CD56(dim) NK cell subset is thought to mediate antitumor responses, whereas the CD56(bright) subset is involved in immunomodulation. Here, we challenge this paradigm...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Principais autores: Wagner, Julia A., Rosario, Maximillian, Romee, Rizwan, Berrien-Elliott, Melissa M., Schneider, Stephanie E., Leong, Jeffrey W., Sullivan, Ryan P., Jewell, Brea A., Becker-Hapak, Michelle, Schappe, Timothy, Abdel-Latif, Sara, Ireland, Aaron R., Jaishankar, Devika, King, Justin A., Vij, Ravi, Clement, Dennis, Goodridge, Jodie, Malmberg, Karl-Johan, Wong, Hing C., Fehniger, Todd A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663359/
https://ncbi.nlm.nih.gov/pubmed/28972539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI90387
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