CD56(bright) NK cells exhibit potent antitumor responses following IL-15 priming

NK cells, lymphocytes of the innate immune system, are important for defense against infectious pathogens and cancer. Classically, the CD56(dim) NK cell subset is thought to mediate antitumor responses, whereas the CD56(bright) subset is involved in immunomodulation. Here, we challenge this paradigm...

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Publicat a:J Clin Invest
Autors principals: Wagner, Julia A., Rosario, Maximillian, Romee, Rizwan, Berrien-Elliott, Melissa M., Schneider, Stephanie E., Leong, Jeffrey W., Sullivan, Ryan P., Jewell, Brea A., Becker-Hapak, Michelle, Schappe, Timothy, Abdel-Latif, Sara, Ireland, Aaron R., Jaishankar, Devika, King, Justin A., Vij, Ravi, Clement, Dennis, Goodridge, Jodie, Malmberg, Karl-Johan, Wong, Hing C., Fehniger, Todd A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663359/
https://ncbi.nlm.nih.gov/pubmed/28972539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI90387
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