Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome

BACKGROUND: DNA methylation is an epigenetic mechanism central to development and maintenance of complex mammalian tissues, but our understanding of its role in intestinal development is limited. RESULTS: We use whole genome bisulfite sequencing, and find that differentiation of mouse colonic intest...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Yu, Da-Hai, Gadkari, Manasi, Zhou, Quan, Yu, Shiyan, Gao, Nan, Guan, Yongtao, Schady, Deborah, Roshan, Tony N., Chen, Miao-Hsueh, Laritsky, Eleonora, Ge, Zhongqi, Wang, Hui, Chen, Rui, Westwater, Caroline, Bry, Lynn, Waterland, Robert A., Moriarty, Chelsea, Hwang, Cindy, Swennes, Alton G., Moore, Sean R., Shen, Lanlan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589031/
https://ncbi.nlm.nih.gov/pubmed/26420038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0763-5
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