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Targeted p16(Ink4a) epimutation causes tumorigenesis and reduces survival in mice
Cancer has long been viewed as a genetic disease; however, epigenetic silencing as the result of aberrant promoter DNA methylation is frequently associated with cancer development, suggesting an epigenetic component to the disease. Nonetheless, it has remained unclear whether an epimutation (an aber...
Gorde:
| Egile Nagusiak: | , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Society for Clinical Investigation
2014
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4151219/ https://ncbi.nlm.nih.gov/pubmed/25061879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76507 |
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