Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite’s food vacuole and alter drug sensitivities

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, are the major determinant of chloroquine resistance in this lethal human malaria parasite. Here, we describe P. falciparum lines subjected to selection by amantadine or blasticidin that carry PfCRT mutations (C101F or...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Pulcini, Serena, Staines, Henry M., Lee, Andrew H., Shafik, Sarah H., Bouyer, Guillaume, Moore, Catherine M., Daley, Daniel A., Hoke, Matthew J., Altenhofen, Lindsey M., Painter, Heather J., Mu, Jianbing, Ferguson, David J. P., Llinás, Manuel, Martin, Rowena E., Fidock, David A., Cooper, Roland A., Krishna, Sanjeev
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588581/
https://ncbi.nlm.nih.gov/pubmed/26420308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14552
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky