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Involvement of Potassium and Cation Channels in Hippocampal Abnormalities of Embryonic Ts65Dn and Tc1 Trisomic Mice

Down syndrome (DS) mouse models exhibit cognitive deficits, and are used for studying the neuronal basis of DS pathology. To understand the differences in the physiology of DS model neurons, we used dissociated neuronal cultures from the hippocampi of Ts65Dn and Tc1 DS mice. Imaging of [Ca(2+)]i and...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Stern, Shani, Segal, Menahem, Moses, Elisha
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588457/
https://ncbi.nlm.nih.gov/pubmed/26501103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.07.038
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