A radiolabeled antibody targeting CD123(+) leukemia stem cells – initial radioimmunotherapy studies in NOD/SCID mice engrafted with primary human AML

Radioimmunotherapy (RIT) with anti-CD123 monoclonal antibody CSL360 modified with nuclear translocation sequence (NLS) peptides and labeled with the Auger electron-emitter, (111)In ((111)In-NLS-CSL360) was studied in the prevalent NOD/SCID mouse AML engraftment assay. Significant decreases in CD123(...

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Detalhes bibliográficos
Publicado no:Leuk Res Rep
Main Authors: Leyton, Jeffrey V., Gao, Catherine, Williams, Brent, Keating, Armand, Minden, Mark, Reilly, Raymond M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588397/
https://ncbi.nlm.nih.gov/pubmed/26500848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lrr.2015.07.003
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