HDAC inhibitor–dependent transcriptome and memory reinstatement in cognitive decline models

Aging and increased amyloid burden are major risk factors for cognitive diseases such as Alzheimer’s disease (AD). Effective therapies for these diseases are lacking. Here, we evaluated mouse models of age-associated memory impairment and amyloid deposition to study transcriptome and cell type–speci...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Benito, Eva, Urbanke, Hendrik, Ramachandran, Binu, Barth, Jonas, Halder, Rashi, Awasthi, Ankit, Jain, Gaurav, Capece, Vincenzo, Burkhardt, Susanne, Navarro-Sala, Magdalena, Nagarajan, Sankari, Schütz, Anna-Lena, Johnsen, Steven A., Bonn, Stefan, Lührmann, Reinhardt, Dean, Camin, Fischer, André
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588238/
https://ncbi.nlm.nih.gov/pubmed/26280576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI79942
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