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De-regulation of gene expression and alternative splicing affects distinct cellular pathways in the aging hippocampus

Aging is accompanied by gradually increasing impairment of cognitive abilities and constitutes the main risk factor of neurodegenerative conditions like Alzheimer's disease (AD). The underlying mechanisms are however not well understood. Here we analyze the hippocampal transcriptome of young ad...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Stilling, Roman M., Benito, Eva, Gertig, Michael, Barth, Jonas, Capece, Vincenzo, Burkhardt, Susanne, Bonn, Stefan, Fischer, Andre
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230043/
https://ncbi.nlm.nih.gov/pubmed/25431548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00373
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