De-regulation of gene expression and alternative splicing affects distinct cellular pathways in the aging hippocampus

Aging is accompanied by gradually increasing impairment of cognitive abilities and constitutes the main risk factor of neurodegenerative conditions like Alzheimer's disease (AD). The underlying mechanisms are however not well understood. Here we analyze the hippocampal transcriptome of young ad...

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Veröffentlicht in:Front Cell Neurosci
Hauptverfasser: Stilling, Roman M., Benito, Eva, Gertig, Michael, Barth, Jonas, Capece, Vincenzo, Burkhardt, Susanne, Bonn, Stefan, Fischer, Andre
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2014
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230043/
https://ncbi.nlm.nih.gov/pubmed/25431548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00373
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