De-regulation of gene expression and alternative splicing affects distinct cellular pathways in the aging hippocampus

Aging is accompanied by gradually increasing impairment of cognitive abilities and constitutes the main risk factor of neurodegenerative conditions like Alzheimer's disease (AD). The underlying mechanisms are however not well understood. Here we analyze the hippocampal transcriptome of young ad...

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Publicado en:Front Cell Neurosci
Autores principales: Stilling, Roman M., Benito, Eva, Gertig, Michael, Barth, Jonas, Capece, Vincenzo, Burkhardt, Susanne, Bonn, Stefan, Fischer, Andre
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230043/
https://ncbi.nlm.nih.gov/pubmed/25431548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00373
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