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De-regulation of gene expression and alternative splicing affects distinct cellular pathways in the aging hippocampus

Aging is accompanied by gradually increasing impairment of cognitive abilities and constitutes the main risk factor of neurodegenerative conditions like Alzheimer's disease (AD). The underlying mechanisms are however not well understood. Here we analyze the hippocampal transcriptome of young ad...

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Bibliografiske detaljer
Udgivet i:Front Cell Neurosci
Main Authors: Stilling, Roman M., Benito, Eva, Gertig, Michael, Barth, Jonas, Capece, Vincenzo, Burkhardt, Susanne, Bonn, Stefan, Fischer, Andre
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230043/
https://ncbi.nlm.nih.gov/pubmed/25431548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00373
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