Enhancement of Blood–Brain Barrier Permeability and Delivery of Antisense Oligonucleotides or Plasmid DNA to the Brain by the Combination of Bubble Liposomes and High-Intensity Focused Ultrasound

The blood–brain barrier (BBB) is a major obstacle that prevents therapeutic drugs or genes from being delivered to the central nervous system. Therefore, it is important to develop methods to enhance the permeability of the BBB. We have developed echo-contrast gas (C(3)F(8)) entrapping liposomes (Bu...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutics
Main Authors: Negishi, Yoichi, Yamane, Masaya, Kurihara, Naho, Endo-Takahashi, Yoko, Sashida, Sanae, Takagi, Norio, Suzuki, Ryo, Maruyama, Kazuo
Format: Artigo
Language:Inglês
Published: MDPI 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588205/
https://ncbi.nlm.nih.gov/pubmed/26402694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics7030344
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items