Ternary Complexes of pDNA, Neuron-Binding Peptide, and PEGylated Polyethyleneimine for Brain Delivery with Nano-Bubbles and Ultrasound

In brain-targeted delivery, the transport of drugs or genes across the blood−brain barrier (BBB) is a major obstacle. Recent reports found that focused ultrasound (FUS) with microbubbles enables transient BBB opening and improvement of drug or gene delivery. We previously developed nano-sized bubble...

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Bibliographic Details
Published in:Pharmaceutics
Main Authors: Endo-Takahashi, Yoko, Kurokawa, Ryo, Sato, Kanako, Takizawa, Nao, Katagiri, Fumihiko, Hamano, Nobuhito, Suzuki, Ryo, Maruyama, Kazuo, Nomizu, Motoyoshi, Takagi, Norio, Negishi, Yoichi
Format: Artigo
Language:Inglês
Published: MDPI 2021
Subjects:
Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8309135/
https://ncbi.nlm.nih.gov/pubmed/34371694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13071003
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