Toxicological Studies of (212)Pb Intravenously or Intraperitoneally Injected into Mice for a Phase 1 Trial

Faced with the novelty of a (212)Pb-labeled monoclonal antibody (mAb) for clinical translation, concerns were expressed by the Food and Drug Administration (FDA) regarding (212)Pb prematurely released from the mAb-chelate conjugate. The objective of this study was to simulate the worst case scenario...

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Detalhes bibliográficos
Publicado no:Pharmaceuticals (Basel)
Main Authors: Milenic, Diane E., Molinolo, Alfredo A., Solivella, María S., Banaga, Eileen, Torgue, Julien, Besnainou, Sarah, Brechbiel, Martin W., Baidoo, Kwamena E.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588175/
https://ncbi.nlm.nih.gov/pubmed/26213947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph8030416
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