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Sensitization of Tumor to (212)Pb-radioimmunotherapy by gemcitabine involves initial abrogation of G2 arrest and blocked DNA damage repair by interference with Rad51
PURPOSE: To elucidate the mechanism of the therapeutic efficacy of targeted α-particle radiation therapy using (212)Pb-TCMC-trastuzumab together with gemcitabine (Gem) for treatment of disseminated peritoneal cancers. METHODS AND MATERIALS: Mice bearing human colon cancer LS-174T i.p. xenografts wer...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3594422/ https://ncbi.nlm.nih.gov/pubmed/23200172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2012.09.015 |
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