Inactivation of NF-κB p65 (RelA) in Liver Improves Insulin Sensitivity and Inhibits cAMP/PKA Pathway

The transcription factor nuclear factor-κB (NF-κB) mediates inflammation and stress signals in cells. To test NF-κB in the control of hepatic insulin sensitivity, we inactivated NF-κB in the livers of C57BL/6 mice through deletion of the p65 gene, which was achieved by crossing floxed-p65 and Alb-cr...

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Bibliographische Detailangaben
Veröffentlicht in:Diabetes
Hauptverfasser: Ke, Bilun, Zhao, Zhiyun, Ye, Xin, Gao, Zhanguo, Manganiello, Vincent, Wu, Bin, Ye, Jianping
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2015
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587638/
https://ncbi.nlm.nih.gov/pubmed/26038580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-0242
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