Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in β-Cells

Mitophagy is a critical regulator of mitochondrial quality control and is necessary for elimination of dysfunctional mitochondria to maintain cellular respiration. Here, we report that the homeodomain transcription factor Pdx1, a gene associated with both type 2 diabetes and monogenic diabetes of th...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Diabetes
Prif Awduron: Soleimanpour, Scott A., Ferrari, Alana M., Raum, Jeffrey C., Groff, David N., Yang, Juxiang, Kaufman, Brett A., Stoffers, Doris A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Diabetes Association 2015
Pynciau:
Islet Studies
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587637/
https://ncbi.nlm.nih.gov/pubmed/26085571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-0376
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