Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas

To explore the potential of tumor-specific DNA as a biomarker for head and neck squamous cell carcinomas (HNSCC), we queried DNA from saliva or plasma of 93 HNSCC patients. We searched for somatic mutations or human papillomavirus genes, collectively referred to as tumor DNA. When both plasma and sa...

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Bibliografiske detaljer
Udgivet i:Sci Transl Med
Main Authors: Wang, Yuxuan, Springer, Simeon, Mulvey, Carolyn L., Silliman, Natalie, Schaefer, Joy, Sausen, Mark, James, Nathan, Rettig, Eleni M., Guo, Theresa, Pickering, Curtis R., Bishop, Justin A., Chung, Christine H., Califano, Joseph A., Eisele, David W., Fakhry, Carole, Gourin, Christine G., Ha, Patrick K., Kang, Hyunseok, Kiess, Ana, Koch, Wayne M., Myers, Jeffrey N., Quon, Harry, Richmon, Jeremy D., Sidransky, David, Tufano, Ralph P., Westra, William H., Bettegowda, Chetan, Diaz, Luis A., Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Agrawal, Nishant
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587492/
https://ncbi.nlm.nih.gov/pubmed/26109104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa8507
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