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Beyond genomics: critical evaluation of cell line utility for ovarian cancer research

OBJECTIVE: Comparisons of The Cancer Genome Atlas (TCGA) with high grade serous ovarian cancer (HGSOC) cell lines used in research reveal that many common experimental models lack defining genomic characteristics seen in patient tumors. As cell lines exist with higher genomic fidelity to TCGA, this...

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Bibliographic Details
Published in:Gynecol Oncol
Main Authors: Elias, Kevin M., Emori, Megan M., Papp, Eniko, MacDuffie, Emily, Konecny, Gottfried E., Velculescu, Victor E., Drapkin, Ronny
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587360/
https://ncbi.nlm.nih.gov/pubmed/26321251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2015.08.017
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