Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer

Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K) have been shown to transform human mammary epithelial cells (MECs). These mutations are present in all breast cancer subtypes, including basal-like breast cancer (BLBC). Using liquid chromatography...

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書誌詳細
出版年:Mol Cell Proteomics
主要な著者: Young, Christian D., Zimmerman, Lisa J., Hoshino, Daisuke, Formisano, Luigi, Hanker, Ariella B., Gatza, Michael L., Morrison, Meghan M., Moore, Preston D., Whitwell, Corbin A., Dave, Bhuvanesh, Stricker, Thomas, Bhola, Neil E., Silva, Grace O., Patel, Premal, Brantley-Sieders, Dana M., Levin, Maren, Horiates, Marina, Palma, Norma A., Wang, Kai, Stephens, Philip J., Perou, Charles M., Weaver, Alissa M., O'Shaughnessy, Joyce A., Chang, Jenny C., Park, Ben Ho, Liebler, Daniel C., Cook, Rebecca S., Arteaga, Carlos L.
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Biochemistry and Molecular Biology 2015
主題:
Research
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587316/
https://ncbi.nlm.nih.gov/pubmed/25953087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.049783
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