Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer

Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K) have been shown to transform human mammary epithelial cells (MECs). These mutations are present in all breast cancer subtypes, including basal-like breast cancer (BLBC). Using liquid chromatography...

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Publicado en:Mol Cell Proteomics
Autores principales: Young, Christian D., Zimmerman, Lisa J., Hoshino, Daisuke, Formisano, Luigi, Hanker, Ariella B., Gatza, Michael L., Morrison, Meghan M., Moore, Preston D., Whitwell, Corbin A., Dave, Bhuvanesh, Stricker, Thomas, Bhola, Neil E., Silva, Grace O., Patel, Premal, Brantley-Sieders, Dana M., Levin, Maren, Horiates, Marina, Palma, Norma A., Wang, Kai, Stephens, Philip J., Perou, Charles M., Weaver, Alissa M., O'Shaughnessy, Joyce A., Chang, Jenny C., Park, Ben Ho, Liebler, Daniel C., Cook, Rebecca S., Arteaga, Carlos L.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2015
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587316/
https://ncbi.nlm.nih.gov/pubmed/25953087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.049783
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