Unique potential of 4-1BB agonist antibody to promote durable regression of HPV(+) tumors when combined with an E6/E7 peptide vaccine

Antibody modulation of T-cell coinhibitory (e.g., CTLA-4) or costimulatory (e.g., 4-1BB) receptors promotes clinical responses to a variety of cancers. Therapeutic cancer vaccination, in contrast, has produced limited clinical benefit and no curative therapies. The E6 and E7 oncoproteins of human pa...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Bartkowiak, Todd, Singh, Shailbala, Yang, Guojun, Galvan, Gloria, Haria, Dhwani, Ai, Midan, Allison, James P., Sastry, K. Jagannadha, Curran, Michael A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586868/
https://ncbi.nlm.nih.gov/pubmed/26351680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514418112
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