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Unique potential of 4-1BB agonist antibody to promote durable regression of HPV(+) tumors when combined with an E6/E7 peptide vaccine
Antibody modulation of T-cell coinhibitory (e.g., CTLA-4) or costimulatory (e.g., 4-1BB) receptors promotes clinical responses to a variety of cancers. Therapeutic cancer vaccination, in contrast, has produced limited clinical benefit and no curative therapies. The E6 and E7 oncoproteins of human pa...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4586868/ https://ncbi.nlm.nih.gov/pubmed/26351680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514418112 |
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