Prophylactic Sublingual Immunization with Mycobacterium tuberculosis Subunit Vaccine Incorporating the Natural Killer T Cell Agonist Alpha-Galactosylceramide Enhances Protective Immunity to Limit Pulmonary and Extra-Pulmonary Bacterial Burden in Mice

Infection by Mycobacterium tuberculosis (Mtb) remains a major global concern and the available Bacillus Calmette-Guerin (BCG) vaccine is poorly efficacious in adults. Therefore, alternative vaccines and delivery strategies focusing on Mtb antigens and appropriate immune stimulating adjuvants are nee...

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Detalhes bibliográficos
Publicado no:Vaccines (Basel)
Main Authors: Khan, Arshad, Singh, Shailbala, Galvan, Gloria, Jagannath, Chinnaswamy, Sastry, K. Jagannadha
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748613/
https://ncbi.nlm.nih.gov/pubmed/29210987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/vaccines5040047
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