In vivo RNAi screening identifies MDA5 as a significant contributor to the cellular defense against influenza A virus

Responding to an influenza A virus (IAV) infection demands an effective intrinsic cellular defense strategy to slow replication. To identify contributing host factors to this defense, we exploited the host microRNA pathway to perform an in vivo RNAi screen. To this end, IAV, lacking a functional NS1...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Benitez, Asiel A., Panis, Maryline, Xue, Jia, Varble, Andrew, Shim, Jaehee V., Frick, Amy L., López, Carolina B., Sachs, David, tenOever, Benjamin R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586153/
https://ncbi.nlm.nih.gov/pubmed/26074083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.05.032
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