Tryptophan Substitutions at Lipid-exposed Positions of the Gamma M3 Transmembrane Domain Increase the Macroscopic Ionic Current Response of the Torpedo californica Nicotinic Acetylcholine Receptor

Our previous amino-acid substitutions at the postulated lipid-exposed transmembrane segment M4 of the Torpedo californica acetylcholine receptor (AChR) focused on the alpha subunit. In this study we have extended the mutagenesis analysis using single tryptophan replacements in seven positions (I288,...

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Publicado en:J Membr Biol
Autores principales: Cruz-Martín, A., Mercado, J.L., Rojas, L.V., McNamee, M.G., Lasalde-Dominicci, J.A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2001
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586063/
https://ncbi.nlm.nih.gov/pubmed/11547353
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