Targeting RNA for degradation with a (2'-5')oligoadenylate-antisense chimera.
Antisense oligonucleotides hold considerable promise both as research tools for inhibiting gene expression and as agents for the treatment of a myriad of human diseases. However, targeted destruction of RNA has been difficult to achieve in a versatile, efficient, and reliable manner. We have develop...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1993
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45860/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7679499/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.4.1300 |
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