Targeting RNA for degradation with a (2'-5')oligoadenylate-antisense chimera.

Antisense oligonucleotides hold considerable promise both as research tools for inhibiting gene expression and as agents for the treatment of a myriad of human diseases. However, targeted destruction of RNA has been difficult to achieve in a versatile, efficient, and reliable manner. We have develop...

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Библиографические подробности
Главные авторы: Torrence, P F, Maitra, R K, Lesiak, K, Khamnei, S, Zhou, A, Silverman, R H
Формат: Artigo
Язык:Inglês
Опубликовано: 1993
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC45860/
https://ncbi.nlm.nih.gov/pubmed/7679499
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