Human Induced Pluripotent Stem Cell Derived Neuronal Cells Cultured on Chemically-Defined Hydrogels for Sensitive In Vitro Detection of Botulinum Neurotoxin

Botulinum neurotoxin (BoNT) detection provides a useful model for validating cell-based neurotoxicity screening approaches, as sensitivity is dependent on functionally competent neurons and clear quantitative endpoints are available for correlating results to approved animal testing protocols. Here,...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Pellett, Sabine, Schwartz, Michael P., Tepp, William H., Josephson, Richard, Scherf, Jacob M., Pier, Christina L., Thomson, James A., Murphy, William L., Johnson, Eric A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585966/
https://ncbi.nlm.nih.gov/pubmed/26411797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14566
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