Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme

Angiotensin-I converting enzyme (ACE) is a zinc dipeptidylcarboxypeptidase with two active domains and plays a key role in the regulation of blood pressure and electrolyte homeostasis, making it the principal target in the treatment of cardiovascular disease. More recently, the tetrapetide N-acetyl-...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Masuyer, Geoffrey, Douglas, Ross G., Sturrock, Edward D., Acharya, K. Ravi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585900/
https://ncbi.nlm.nih.gov/pubmed/26403559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13742
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