Small cell lung cancer transformation and T790M mutation: complimentary roles in acquired resistance to kinase inhibitors in lung cancer

Lung cancers often harbour a mutation in the epidermal growth factor receptor (EGFR) gene. Because proliferation and survival of lung cancers with EGFR mutation solely depend on aberrant signalling from the mutated EGFR, these tumours often show dramatic responses to EGFR tyrosine kinase inhibitors...

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Udgivet i:Sci Rep
Main Authors: Suda, Kenichi, Murakami, Isao, Sakai, Kazuko, Mizuuchi, Hiroshi, Shimizu, Shigeki, Sato, Katsuaki, Tomizawa, Kenji, Tomida, Shuta, Yatabe, Yasushi, Nishio, Kazuto, Mitsudomi, Tetsuya
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585860/
https://ncbi.nlm.nih.gov/pubmed/26400668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14447
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