Oncogene swap as a novel mechanism of acquired resistance to epidermal growth factor receptor‐tyrosine kinase inhibitor in lung cancer

Mutant selective epidermal growth factor receptor‐tyrosine kinase inhibitors (EGFR‐TKIs), such as rociletinib and AZD9291, are effective for tumors with T790M secondary mutation that become refractory to first‐generation EGFR‐TKI. However, acquired resistance to these prospective drugs is anticipate...

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Veröffentlicht in:Cancer Sci
Hauptverfasser: Mizuuchi, Hiroshi, Suda, Kenichi, Murakami, Isao, Sakai, Kazuko, Sato, Katsuaki, Kobayashi, Yoshihisa, Shimoji, Masaki, Chiba, Masato, Sesumi, Yuichi, Tomizawa, Kenji, Takemoto, Toshiki, Sekido, Yoshitaka, Nishio, Kazuto, Mitsudomi, Tetsuya
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832847/
https://ncbi.nlm.nih.gov/pubmed/26845230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12905
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