Small cell lung cancer transformation and T790M mutation: complimentary roles in acquired resistance to kinase inhibitors in lung cancer

Lung cancers often harbour a mutation in the epidermal growth factor receptor (EGFR) gene. Because proliferation and survival of lung cancers with EGFR mutation solely depend on aberrant signalling from the mutated EGFR, these tumours often show dramatic responses to EGFR tyrosine kinase inhibitors...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Suda, Kenichi, Murakami, Isao, Sakai, Kazuko, Mizuuchi, Hiroshi, Shimizu, Shigeki, Sato, Katsuaki, Tomizawa, Kenji, Tomida, Shuta, Yatabe, Yasushi, Nishio, Kazuto, Mitsudomi, Tetsuya
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2015
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585860/
https://ncbi.nlm.nih.gov/pubmed/26400668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14447
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