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Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine
Methylene blue, currently in phase 3 clinical trials against Alzheimer Disease, disaggregates the Tau protein of neurofibrillary tangles by oxidizing specific cysteine residues. Here, we investigated if methylene blue can inhibit caspases via the oxidation of their active site cysteine. Methylene bl...
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| Gepubliceerd in: | Sci Rep |
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| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4585840/ https://ncbi.nlm.nih.gov/pubmed/26400108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13730 |
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