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A novel stearic acid-modified hirudin peptidomimetic with improved pharmacokinetic properties and anticoagulant activity
A novel hirudin isoform 3 mimetic peptide, named peptide S2, has been prepared by introduction of a stearic acid modification. Peptide S2 exhibited superior inhibitory activity to hirulog-1 (Bivariludin) and showed significantly higher anticoagulant potency in vivo. Peptide S2 elevated the thrombin...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4585835/ https://ncbi.nlm.nih.gov/pubmed/26400022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14349 |
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