A novel stearic acid-modified hirudin peptidomimetic with improved pharmacokinetic properties and anticoagulant activity

A novel hirudin isoform 3 mimetic peptide, named peptide S2, has been prepared by introduction of a stearic acid modification. Peptide S2 exhibited superior inhibitory activity to hirulog-1 (Bivariludin) and showed significantly higher anticoagulant potency in vivo. Peptide S2 elevated the thrombin...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Liu, Zhuguo, Yu, Zheng, Huang, Yuanyuan, Zhang, Yan, Han, Guozhu, Li, Xian, Dong, Mingxin, Yu, Shuo, Wang, Yu, Hu, Jie, Guo, Huiqin, Cheng, Yuanguo, Lv, Li, Dai, Qiuyun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585835/
https://ncbi.nlm.nih.gov/pubmed/26400022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14349
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