Calreticulin is required for development of the cumulus oocyte complex and female fertility

Calnexin (CANX) and calreticulin (CALR) chaperones mediate nascent glycoprotein folding in the endoplasmic reticulum. Here we report that these chaperones have distinct roles in male and female fertility. Canx null mice are growth retarded but fertile. Calr null mice die during embryonic development...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tokuhiro, Keizo, Satouh, Yuhkoh, Nozawa, Kaori, Isotani, Ayako, Fujihara, Yoshitaka, Hirashima, Yumiko, Matsumura, Hiroyuki, Takumi, Kazuhiro, Miyano, Takashi, Okabe, Masaru, Benham, Adam M., Ikawa, Masahito
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585710/
https://ncbi.nlm.nih.gov/pubmed/26388295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14254
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