Multigene panel analysis identified germline mutations of DNA repair genes in breast and ovarian cancer

Approximately 5–10% of all breast and/or ovarian cancer cases are considered as inherited. BRCA1 and BRCA2 tumor suppressor genes account for a high penetrance of hereditary cases, but familial cases without mutations in these genes can also occur. Despite their low penetrance, other hereditary canc...

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Publicat a:Mol Genet Genomic Med
Autors principals: Hirotsu, Yosuke, Nakagomi, Hiroshi, Sakamoto, Ikuko, Amemiya, Kenji, Oyama, Toshio, Mochizuki, Hitoshi, Omata, Masao
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Ltd 2015
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585454/
https://ncbi.nlm.nih.gov/pubmed/26436112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mgg3.157
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