Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures

Neto2 is a transmembrane protein that interacts with the neuron-specific K(+)-Cl(−) cotransporter (KCC2) in the central nervous system (CNS). Efficient KCC2 transport is essential for setting the neuronal Cl(−) gradient, which is required for fast GABAergic inhibition. Neto2 is required to maintain...

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Udgivet i:Front Cell Neurosci
Main Authors: Mahadevan, Vivek, Dargaei, Zahra, Ivakine, Evgueni A., Hartmann, Anna-Maria, Ng, David, Chevrier, Jonah, Ormond, Jake, Nothwang, Hans Gerd, McInnes, Roderick R., Woodin, Melanie A.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2015
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585209/
https://ncbi.nlm.nih.gov/pubmed/26441539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00368
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