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Restoring GABAergic inhibition rescues memory deficits in a Huntington’s disease mouse model
Huntington’s disease (HD) is classically characterized as a movement disorder, however cognitive impairments precede the motor symptoms by ∼15 y. Based on proteomic and bioinformatic data linking the Huntingtin protein (Htt) and KCC2, which is required for hyperpolarizing GABAergic inhibition, and t...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5816181/ https://ncbi.nlm.nih.gov/pubmed/29382760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716871115 |
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