Genome-wide maps of nuclear lamina interactions in single human cells

Mammalian interphase chromosomes interact with the nuclear lamina (NL) through hundreds of large Lamina Associated Domains (LADs). We report a method to map NL contacts genome-wide in single human cells. Analysis of nearly 400 maps reveals a core architecture of gene-poor LADs that contact the NL wi...

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Bibliografiska uppgifter
I publikationen:Cell
Huvudupphovsmän: Kind, Jop, Pagie, Ludo, de Vries, Sandra S., Nahidiazar, Leila, Dey, Siddharth S., Bienko, Magda, Zhan, Ye, Lajoie, Bryan, de Graaf, Carolyn A., Amendola, Mario, Fudenberg, Geoffrey, Imakaev, Maxim, Mirny, Leonid A., Jalink, Kees, Dekker, Job, van Oudenaarden, Alexander, van Steensel, Bas
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583798/
https://ncbi.nlm.nih.gov/pubmed/26365489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.08.040
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