Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma

Fifty percent of cutaneous melanomas are driven by activated BRAF (V600E), but tumors treated with RAF inhibitors, even when they respond dramatically, rapidly adapt and develop resistance. Thus, there is a pressing need to identify the major mechanisms of intrinsic and adaptive resistance and devel...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Capaldo, Brian J., Roller, Devin, Axelrod, Mark J., Koeppel, Alex F., Petricoin, Emanuel F., Slingluff, Craig L., Weber, Michael J., Mackey, Aaron J., Gioeli, Daniel, Bekiranov, Stefan
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583389/
https://ncbi.nlm.nih.gov/pubmed/26405815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138210
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