Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma

Fifty percent of cutaneous melanomas are driven by activated BRAF (V600E), but tumors treated with RAF inhibitors, even when they respond dramatically, rapidly adapt and develop resistance. Thus, there is a pressing need to identify the major mechanisms of intrinsic and adaptive resistance and devel...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Capaldo, Brian J., Roller, Devin, Axelrod, Mark J., Koeppel, Alex F., Petricoin, Emanuel F., Slingluff, Craig L., Weber, Michael J., Mackey, Aaron J., Gioeli, Daniel, Bekiranov, Stefan
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583389/
https://ncbi.nlm.nih.gov/pubmed/26405815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138210
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