Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma

Fifty percent of cutaneous melanomas are driven by activated BRAF (V600E), but tumors treated with RAF inhibitors, even when they respond dramatically, rapidly adapt and develop resistance. Thus, there is a pressing need to identify the major mechanisms of intrinsic and adaptive resistance and devel...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Capaldo, Brian J., Roller, Devin, Axelrod, Mark J., Koeppel, Alex F., Petricoin, Emanuel F., Slingluff, Craig L., Weber, Michael J., Mackey, Aaron J., Gioeli, Daniel, Bekiranov, Stefan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583389/
https://ncbi.nlm.nih.gov/pubmed/26405815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138210
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