Targeted Knock-Down of miR21 Primary Transcripts Using snoMEN Vectors Induces Apoptosis in Human Cancer Cell Lines

We have previously reported an antisense technology, ‘snoMEN vectors’, for targeted knock-down of protein coding mRNAs using human snoRNAs manipulated to contain short regions of sequence complementarity with the mRNA target. Here we characterise the use of snoMEN vectors to target the knock-down of...

Full description

Saved in:
Bibliographic Details
Published in:PLoS One
Main Authors: Ono, Motoharu, Yamada, Kayo, Avolio, Fabio, Afzal, Vackar, Bensaddek, Dalila, Lamond, Angus I.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583369/
https://ncbi.nlm.nih.gov/pubmed/26405811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138668
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items