Targeted Knock-Down of miR21 Primary Transcripts Using snoMEN Vectors Induces Apoptosis in Human Cancer Cell Lines

We have previously reported an antisense technology, ‘snoMEN vectors’, for targeted knock-down of protein coding mRNAs using human snoRNAs manipulated to contain short regions of sequence complementarity with the mRNA target. Here we characterise the use of snoMEN vectors to target the knock-down of...

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Udgivet i:PLoS One
Main Authors: Ono, Motoharu, Yamada, Kayo, Avolio, Fabio, Afzal, Vackar, Bensaddek, Dalila, Lamond, Angus I.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583369/
https://ncbi.nlm.nih.gov/pubmed/26405811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138668
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