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The Selective Degradation of Synaptic Connexin 43 Protein by Hypoxia-induced Autophagy Impairs Natural Killer Cell-mediated Tumor Cell Killing

Although natural killer (NK) cells play an important role in the control of melanoma, hypoxic stress in the tumor microenvironment may impair NK-mediated tumor cell killing by mechanisms that are not fully understood. In this study, we investigated the effect of hypoxia on the expression and channel...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Tittarelli, Andrés, Janji, Bassam, Van Moer, Kris, Noman, Muhammad Zaeem, Chouaib, Salem
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583044/
https://ncbi.nlm.nih.gov/pubmed/26221040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.651547
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