Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia

Recent studies demonstrated that autophagy is an important regulator of innate immune response. However, the mechanism by which autophagy regulates natural killer (NK) cell-mediated antitumor immune responses remains elusive. Here, we demonstrate that hypoxia impairs breast cancer cell susceptibilit...

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Autori principali: Baginska, Joanna, Viry, Elodie, Berchem, Guy, Poli, Aurélie, Noman, Muhammad Zaeem, van Moer, Kris, Medves, Sandrine, Zimmer, Jacques, Oudin, Anaïs, Niclou, Simone P., Bleackley, R. Chris, Goping, Ing Swie, Chouaib, Salem, Janji, Bassam
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808626/
https://ncbi.nlm.nih.gov/pubmed/24101526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304790110
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