Ambient Light Promotes Selective Subcellular Proteotoxicity after Endogenous and Exogenous Porphyrinogenic Stress

Hepatic accumulation of protoporphyrin-IX (PP-IX) in erythropoietic protoporphyria (EPP) or X-linked-dominant protoporphyria (XLP) cause liver damage. Hepatocyte nuclear lamin aggregation is a sensitive marker for PP-IX-mediated liver injury. We tested the hypothesis that extracellular or intracellu...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Maitra, Dhiman, Elenbaas, Jared S., Whitesall, Steven E., Basrur, Venkatesha, D'Alecy, Louis G., Omary, M. Bishr
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583010/
https://ncbi.nlm.nih.gov/pubmed/26205816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.636001
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